Biological Information

Background Information:

Hematopoietic cell kinase (HCK) is a member of Src protein-tyrosine kinase family and expressed primary in granulocytes, monocytes and macrophages. Active HCK phosphorylates STAT5B on Tyr699, which represents an essential step in Signal transducer and activator of transcription 5 (STAT5B) stimulation. The binding of SH3 ligands, such as the Nef protein of HIV-1, further augments Hck activity suggesting a new mechanism for regulating tyrosine kinase activity. GenBank NM_002110

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

HCK

Protein Aliases:

Hematopoietic cell kinase|Hemopoietic cell kinase|p59-HCK/p60-HCK|p59Hck|p61Hck

Accession Number:

NM_002110.2

UniProt Number:

P08631

Gene Name:

HCK

Gene ID:

3055

Gene Aliases:

JTK9

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy