Biological Information

Background Information:

Homeodomain-interacting protein kinase 3 (HIPK3), a serine/threonine kinase, has been described as a member of a family of nuclear kinases that act as co-repressors for homeodomain transcription factors. HIPK3 can activate p53-mediated transcriptional regulation of MDM2 and antagonize Myc/Ras-induced transformation. HIPK3 may play an important role in the regulation of p53 apoptotic function. Inhibition of HIPK3 may inhibit apoptosis and facilitate tumorigenesis. GenBank NM_005734

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

HIPK3

Protein Aliases:

Androgen receptor-interacting nuclear protein kinase|ANPK|Fas-interacting serine/threonine-protein kinase|FIST|Homolog of protein kinase YAK1

Accession Number:

NM_001048200.1; NM_005734.3

UniProt Number:

Q9H422

Gene Name:

HIPK3

Gene ID:

10114

Gene Aliases:

PKY|DYRK6|YAK1|FIST3

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology