Biological Information

Background Information:

DHX58 (LGP2) is a regulator of RIG-I and MDA5 and is necessary for producing effective antiviral responses against many viruses that are recognized by these two helicases. It can facilitate both negative and positive regulatory functions which is probably dependent on the characteristics of the infecting virus or target cells, or both. The helicase activity of DHX58 (LGP2) has been found to be essential for its positive regulation of RIG-I signaling. Dysregulation/mutation of DHX58 (LGP2), RIG-I and MDA5 has been implicated in abnormal inflammatory responses to viral infections as well as autoimmune diseases.

Target Class:

Helicase

Family:

RLR

Sub Family:

RNA helicase

Protein Aliases:

D11LGP2E, LGP2, RLR, RLR-3

Accession Number:

NM_024119.3

UniProt Number:

Q96C10

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Infection/Inflammation