Biological Information

Background Information:

Mammalian casein kinase 2α1 (CK2a1) is a highly conserved serine-threonine protein kinase that is constitutively expressed in all eukaryotic cell types including yeast, insects, and vertebrates. The enzyme can utilize GTP or ATP as a phosphate donor. Casein kinase activity is stimulated by mitogens in a cell type-specific manner during development and embryogenesis. Inhibition of CK2α1 may be useful in the treatment of human squamous cell carcinoma, adenocarcinoma of the lung, prostatic hyperplasia and lymphomas. GenBank J02853.1

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

CK2alpha1

Accession Number:

J02853

UniProt Number:

P68400

Gene Name:

CSNK2A1

Gene ID:

1457

Gene Aliases:

CK2A1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -20°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology