Biological Information

Background Information:

Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference to GenBank NM_001184.3. M211T is reported in GenBank XM_001131387.1.

Target Class:

Kinase

Family:

PIKK

Sub Family:

Atypical

Protein Name:

ATR

Protein Aliases:

MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae)

Accession Number:

NM_001184.3; AF451323.1

UniProt Number:

Q13535

Gene Name:

ATR

Gene ID:

545

Gene Aliases:

FRP1|SCKL|SCKL1|MEC1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only