Investigate Kinase Targets

World’s Largest Portfolio of Kinase Assays

DiscoveRx offers the most comprehensive menu of in vitro biochemical and cell-based assays for evaluating kinase activity. Our in vitro biochemical kinase panel includes an industry-leading set of 456 assays, allowing rapid and efficient determination of kinome-wide potency and selectivity of compounds. By integrating EFC technology, kinase knowledge, and expertise in cell-based assays, we also offer a growing menu of homogenous, functional assays to detect activated kinases in whole cells. Used alone or in combination, these powerful assay platforms can be used at all stages of drug discovery and are ideal for identifying highly potent and selective kinase inhibitors.

View By Kinase Group

AGC AGC AKT1 AKT2 AKT3 CIT DMPK DMPK2 GRK1 GRK4 GRK7 LATS1 LATS2 MAST1 MRCKA MRCKB NDR1 NDR2 PDPK1 PKAC-alpha PKAC-beta PKN1 PKN2 PRKCD PRKCE PRKCH PRKCI PRKCQ PRKG1 PRKG2 PRKX ROCK1 ROCK2 RPS6KA4(Kin.Dom.1-N-terminal) RPS6KA5(Kin.Dom.1-N-terminal) RSK1(Kin.Dom.1-N-terminal) RSK2(Kin.Dom.1-N-terminal) RSK3(Kin.Dom.1-N-terminal) RSK4(Kin.Dom.1-N-terminal) S6K1 SGK SGK2 SGK3 YANK1 YANK2 YANK3	Atypical Atypical ADCK3 ADCK4 MTOR RIOK1 RIOK2 RIOK3 TRPM6	CAMK CAMK AMPK-alpha1 AMPK-alpha2 ARK5 BRSK1 BRSK2 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 DCAMKL1 DCAMKL2 DCAMKL3 DRAK1 DRAK2 HUNK LKB1 MAPKAPK2 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 MLCK MYLK MYLK2 MYLK4 NIM1 PHKG1 PHKG2 PIM1 PIM2 PIM3 PRKD1 PRKD2 PRKD3 QSK RPS6KA4(Kin.Dom.2-C-terminal) RPS6KA5(Kin.Dom.2-C-terminal) RSK1(Kin.Dom.2-C-terminal) RSK2(Kin.Dom.2-C-terminal) RSK3(Kin.Dom.2-C-terminal) RSK4(Kin.Dom.2-C-terminal) SIK SIK2 SNARK SNRK STK33 TSSK1B	CK1 CK1 CSNK1A1 CSNK1A1L CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 VRK2	CMGC CMGC CDC2L1 CDC2L2 CDC2L5 CDK11 CDK2 CDK3 CDK4-cyclinD1 CDK4-cyclinD3 CDK5 CDK7 CDK8 CDK9 CDKL1 CDKL2 CDKL3 CDKL5 CLK1 CLK2 CLK3 CLK4 DYRK1A DYRK1B DYRK2 ERK1 ERK2 ERK3 ERK4 ERK5 ERK8 GSK3A GSK3B HIPK1 HIPK2 HIPK3 HIPK4 ICK JNK1 JNK2 JNK3 MAK NLK p38-alpha p38-beta p38-delta p38-gamma PCTK1 PCTK2 PCTK3 PFTAIRE2 PFTK1 PRP4 SRPK1 SRPK2 SRPK3
CTK Receptor CTK Receptor	Cytosolic Tyrosine Kinase Cytosolic Tyrosine Kinase BLK FGR JAK3 SYK YES1	Epidermal Growth Factor Epidermal Growth Factor EGFR	Lipid Lipid PIK3C2B PIK3C2G PIK3CA PIK3CA(C420R) PIK3CA(E542K) PIK3CA(E545A) PIK3CA(E545K) PIK3CA(H1047L) PIK3CA(H1047Y) PIK3CA(I800L) PIK3CA(M1043I) PIK3CA(Q546K) PIK3CB PIK3CD PIK3CG PIK4CB PIP5K1A PIP5K1C PIP5K2B PIP5K2C	Other Other AAK1 AURKA AURKB AURKC BIKE BUB1 CAMKK1 CAMKK2 CSNK2A1 CSNK2A2 EIF2AK1 ERN1 GAK GCN2(Kin.Dom.2,S808G) HASPIN IKK-alpha IKK-beta IKK-epsilon NEK1 NEK10 NEK11 NEK2 NEK3 NEK4 NEK5 NEK6 NEK7 NEK9 PKMYT1 PLK1 PLK2 PLK3 PLK4 PRKR RIPK5 SBK1 SgK110 STK16 STK35 STK36 TBK1 TLK1 TLK2 TTK ULK1 ULK2 ULK3 WEE1 WEE2 WNK1 WNK3
Pathogen Pathogen PFCDPK1(P.falciparum) PFPK5(P.falciparum) PKNB(M.tuberculosis)	Receptor Tyrosine Kinase Receptor Tyrosine Kinase AXL KIT MET RET DDR1 DDR2 EGFR EphA4 EphA5 EphA7 EphB1 EphB2 EphB3 EphB4 ERBB2 ErbB2 ERBB3 ERBB4 FGFR1 FLT3 FLT4 IGF1R INSR PDGFRA PDGFRB TRKA TRKB TRKC	Ser/Thr Kinase Ser/Thr Kinase ACVR1 TGFBR1 TGFBR1	STE STE ASK1 ASK2 HPK1 LOK MAP3K1 MAP3K15 MAP3K2 MAP3K3 MAP3K4 MAP4K2 MAP4K3 MAP4K4 MAP4K5 MEK1 MEK2 MEK3 MEK4 MEK5 MEK6 MINK MKK7 MST1 MST2 MST3 MST4 MYO3A MYO3B NIK OSR1 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 SLK STK39 TAOK1 TAOK2 TAOK3 TNIK YSK1 YSK4	TK TK ABL1(E255K)-phosphorylated ABL1(F317I)-nonphosphorylated ABL1(F317I)-phosphorylated ABL1(F317L)-nonphosphorylated ABL1(F317L)-phosphorylated ABL1(H396P)-nonphosphorylated ABL1(H396P)-phosphorylated ABL1(M351T)-phosphorylated ABL1(Q252H)-nonphosphorylated ABL1(Q252H)-phosphorylated ABL1(T315I)-nonphosphorylated ABL1(T315I)-phosphorylated ABL1(Y253F)-phosphorylated ABL1-nonphosphorylated ABL1-phosphorylated ABL2 ALK ALK(C1156Y) ALK(L1196M) AXL BLK BMX BRK BTK CSF1R CSF1R-autoinhibited CSK CTK DDR1 DDR2 EGFR EGFR(E746-A750del) EGFR(G719C) EGFR(G719S) EGFR(L747-E749del, A750P) EGFR(L747-S752del, P753S) EGFR(L747-T751del,Sins) EGFR(L858R) EGFR(L858R,T790M) EGFR(L861Q) EGFR(S752-I759del) EGFR(T790M) EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 ERBB2 ERBB3 ERBB4 FAK FER FES FGFR1 FGFR2 FGFR3 FGFR3(G697C) FGFR4 FGR FLT1 FLT3 FLT3(D835H) FLT3(D835Y) FLT3(ITD) FLT3(K663Q) FLT3(N841I) FLT3(R834Q) FLT3-autoinhibited FLT4 FRK FYN HCK IGF1R INSR INSRR ITK JAK1(JH1domain-catalytic) JAK1(JH2domain-pseudokinase) JAK2(JH1domain-catalytic) JAK3(JH1domain-catalytic) KIT KIT(A829P) KIT(D816H) KIT(D816V) KIT(L576P) KIT(V559D) KIT(V559D,T670I) KIT(V559D,V654A) KIT-autoinhibited LCK LTK LYN MERTK MET MET(M1250T) MET(Y1235D) MST1R MUSK PDGFRA PDGFRB PYK2 RET RET(M918T) RET(V804L) RET(V804M) ROS1 SRC SRMS SYK TEC TIE1 TIE2 TNK1 TNK2 TRKA TRKB TRKC TXK TYK2(JH1domain-catalytic) TYK2(JH2domain-pseudokinase) TYRO3 VEGFR2 YES ZAP70
TKL TKL ACVR1 ACVR1B ACVR2A ACVR2B ACVRL1 ANKK1 BMPR1A BMPR1B BMPR2 BRAF BRAF(V600E) DLK IRAK1 IRAK3 IRAK4 LIMK1 LIMK2 LRRK2 LRRK2(G2019S) LZK MLK1 MLK2 MLK3 RAF1 RIPK1 RIPK2 RIPK4 TAK1 TESK1 TGFBR1 TGFBR2 TNNI3K ZAK

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Cell Lines

Explore our growing panel of target-specific, stable kinase cell lines for measuring the activity of receptor tyrosine kinases (RTKs) and non-receptor cytosolic tyrosine kinases (CTKs).
See how our Tyrosine Kinase assays work >
See how our InCELL Hunter™ assays work >

Assay Ready Kits

PathHunter® eXpress Receptor Tyrosine Kinase and Cytosolic Tyrosine Kinase assays are complete, ready-to-use kits that include all the cells and reagents to measure kinase activation in live cells. Free yourself from lengthy cell culture and expensive instrumentation.
Learn about Assay Ready eXpress™ Kits >
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Biochemical Assays

Study active kinases using our universal ADP accumulation assays. Explore inactive and active kinases with one of our highly quantitative, competitive binding platforms without using antibodies or kinase substrates.
Learn about ADP accumulation assays >

Cell Culture Kits, Reagents & Consumables

Performance you can trust! Get the highest quality data from your cell-based kinase assays in combination with our lab-certified PathHunter® cell culture media, tissue culture reagents and plates.

Ligands & Inhibitors

Designed to target a specific kinase receptor or pathway, our purified reference ligands and inhibitors are a convenient and cost-effective way to validate any stable Kinase cell line or assay-ready kit.
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Inhibitors & Ligands

Detection Reagents

Get optimal assay performance using certified chemiluminescent or fluorescent PathHunter® Detection Reagents that have been validated for use in both 96-well and 384-well microplate formats.
How detection works >

PathHunter® Detection Reagents

Instruments

Get reliable and reproducible results using our 96-well microplate reader that is ideal for all DiscoveRx chemiluminescent assays.

LumiLITE™ Microplate Reader

Targets