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NRF2 Pathway
NRF2 [Nuclear factor (erythroid-derived 2)-like 2] and it's downstream target genes play an important role in cellular anti-oxidant defense, making it a therapeutic target for neurodegenerative diseases and cancer. Variety of environmental factors such as smoking, inflammation, grilled meat, sunlight and oxygen lead to production of free radicals and other highly reactive substances that result in cell damage. Cell damage contributes to diseases such as arteriosclerosis, stroke, asthma, cardiac infarctions, Alzheimer's disease, Parkinson's disease and cancer. NRF2 is a transcription factor. DiscoveRx offers novel direct, functional cellular assays for NRF2 translocation. No more assay development required; a simple mix-and-read micro titer plate-based assay without obtaining gene transcription is now available!
Product Features
Simple pipette-and-read protocols
Multiple formats
• One-step, HTS-ready cell line
Broad applicability
Simple chemiluminescent detection
Applications
Measure effect of compounds on NRF2 activation
Screen or profile compounds against Keap-NRF2 pathway
Obtain toxicity profile of your compounds
Download the user manual 
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