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DiscoveRx Assay Newsletter

Welcome to our second edition of 2010 DiscoveRx Assay Newsletter!
Once again, for your convenience, this issue is packed with information on our new product launches, novel applications, innovative assays that expedite your therapeutic programs and of course our exciting promotions! DiscoveRx continues to be a leading provider
of innovative product and service solution for GPCR, Kinases and NHR. Find out how our simple assay solutions can help you with complex
biological problems!

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Download our posters
on our key product presented at SBS 2010

1. Cell-Based Assays for G-Protein Independent Signaling Using Arrestin Binding and Endocytosis

2. PathHunter™ Cell-Based Kinase Assays: A Portfolio of HTS-friendly Cytoplasmic or Receptor Tyrosine Kinase Assays for Small Molecule Inhibitors as well as Monoclonal Antibodies

3. A Wide Range of Compound Efficacies Revealed Using PathHunter™ Arrestin Assays

4. Unique Properties of PathHunter™ β-Arrestin Assays for GPCR Antagonist Discovery and Characterization

5. PathHunter™ β-Arrestin Assays: Determination of Pharmacology Differences Between Human and Ortholog GPCRs

6. Functional, Cell-Based Pathway Assays Using PathHunter™ Technology

7. HitHunter™ cAMP and cAMP Hunter™ Cell Line: Your Solution for Use with High Serum Samples, Difficult Gi Targets and Identification of Allosteric Modulators

8. ADP Quest™ and ADP Quest™ HS: Universal ADP Accumulation Assay for Enzyme Kinetics

Introducing Novel cell-based PathHunter™ assay for Cytosolic Kinases

Finally a non-ELISA, screen friendly cell-based assay platform for cytokine receptors and the cytosolic tyrosine kinases.

•Saves you months of assay development
–Simple, no wash, one-step and ready-to-screen assays
•Uses Full length receptors and kinases
–Screen for small molecule agonists, inhibitors or functional antibodies
–Identify biologically relevant and specific inhibitors
•One step, Direct Assays without need of Antibodies
–Ideal for monitoring JAK1, JAK2 or JAK3 activity on cytokine receptor phosphorylation

JAK1, JAK2 and cytokine receptors PRLR, CSF3R... Read more»

Over 40 PathHunter™ Activated GPCR Internalization Assays Now Available

•Native, untagged GPCR receptors
•Arrestin-dependent signaling pathway ideal for hit confirmation or tertiary screens
•Gain of Signal assay that detects activated GPCRs in early endosomes
•Simple, single addition protocol
•Low background and large assay windows
•No fixing, imaging or antibody labeling

PathHunter™ Activated GPCR Internalization Assays let you monitor the fate of unlabeled, activated GPCRs in live cells... Read more»

New Targets

New cAMP Hunter™ Gi, Gs and Gq Cell Lines
Human: BRS3, EDG2, FFAR1, FFAR3, PTGER1, RXFP4, SSTR5, 5-HT1A, OPRM1

New PathHunter™ Receptor Tyrosine Kinase Assays
Human: ErbB1, DDR1, DDR2

New PathHunter™ Cytokine Receptors, cytosolic tyrosine kinase assays
Human: CSF3R-JAK1, PRLR-JAK1, PRLR-JAK2

New PathHunter Pathway Assays
Human: FOXO3 translocation, IκB degradation

New PathHunter™ β-Arrestin Assays
Human: BRS3, DRD4, EDG6, 5HT6, HTR1A, HTR1B, HTR1E, HTR1F, HTR5A, LHCGR, MCHR2,
RXFP3, RXFP4
Mouse: ADORA3, CCR6, CX3CR1, CXCR7 (CMKOR1), EDG6, EDNRA, VIPR1

New PathHunter™ Orphan Assays
Human: ADMR (GPR182), GPR6, GPR20, GPR31, GPR50, GPR85, TAAR5

New PathHunter™ Activated GPCR Internalization Assays
Human: AGTRL1, AVPR1B, AVPR2, BDKRB2, C5R1, CCR4, CCKBR, CMKLR1, CRHR1, HCRTR2,
NPY2R, OPRD1, OXTR1, P2RY11, TACR1, VIPR2

New PathHunter™ β-Arrestin eXpress Kits
Human: AVPR2
Mouse: C5AR1
Rat: CRTH2

New EasyScreen™ β-Arrestin Kits
Human: AVPR2, MC1R
Mouse: C5R1
Rat: CRTH2

Click here for a complete list of new product launches