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Learn More About the Unique Advantages of PathHunter™ ß-Arrestin for GPCR Screening

• Large assay windows provide increased confidence in results
• G-Protein-coupling independent-ideal for orphan receptors
• More direct than 2nd messengers means smaller chance of false positives
• Fast and simple with a microplate read out saves time and operating cost

PathHunter™ ß-Arrestin Assays are validated for the following Gi-, Gq-, and Gs-coupled receptors:

PathHunter ß-Arrestin Assays are revolutionary high-throughput screening assays for monitoring GPCR activation following ligand stimulation without an imaging instrument, fluorescent protein tag, or radioactivity. Instead, the assays detect GPCR activation through ß-Arrestin binding to the expressed GPCR of interest, measuring the interaction of the two proteins using enzyme fragment complementation. The single-addition chemiluminescent detection protocol makes the assays ideal for microplate formats.

For more information on PathHunter™ ß-Arrestin assays, download the poster presented at SBS 06:

Development of a non-imaging homogeneous assay format for analysis of arrestin recruitment as a detection method for generic GPCR screening

Please contact your local DiscoveRx sales representative to discuss the pharmacology results for these GPCRs or to request a seminar or on-site demonstration.

Measure Nuclear Receptor Translocation In Vivo

PathHunter™ Nuclear Translocation Assays measure the effects of compounds on the nuclear translocation of a drug target in vivo.

Ready-to-Go Nuclear Hormone Receptor Assays:

ProLabel™ Nuclear Hormone Receptor Vectors:

Please contact your local DiscoveRx sales representative for more information about PathHunter™ Nuclear Translocation Assays or to request a seminar or on-site demonstration.