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Literature

Welcome to our online resource library. The library contains our most popular resources including lists of publications in numerous journals, application notes, posters, online presentations, marketing literature and more. Please use the pull down menu below to access the materials.

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Brochures/Flyers

Title
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PathHunter® GPCR eXplorer Kits

     

See What You are Missing in GPCR Profiling Services

     

NFκB Signaling Pathway: Functional Cell-Based Assays for NFκB Pathway and Other Inflammation Targets

     

DNA Damage Pathway: Unique Functional Cell-Based Assays for DNA Damage Pathway

     

Largest Menu of Functional GPCR Assays For Screening And Profiling

     

PI3 Signaling Pathway: Functional Cell-Based and Biochemical Assays for PI3 Pathway

     

Wnt-Frizzled Signaling Pathway: Functional Cell-Based and Biochemical Assays for Wnt Pathway

     

PathHunter® β-Arrestin Orphan Panel

     

Complete Chemokine GPCR Panel For Profiling Services

     

Largest Menu of Functional GPCR Assays For Screening And Profiling

     

GPCR Screening and Profiling Services

     

PathHunter® β-Arrestin GPCR Panel

     

PathHunter® Nuclear Hormone Receptor (NHR) Assays

     

PathHunter® PCSK9 Cell-Based Protease Assay

     

Dual Mode PathHunter® β-Arrestin GPCR Cell Lines

     

PathHunter® Flash Detection Kit

     

PathHunter® EAstern Blot Assay Kit

     

PathHunter® β-Arrestin Assays Universal Asssay for Virtually Any GPCR

     

The Broadest Panel of Kinase Solutions for Characterization, Profiling & Screening

     

HitHunter® cAMP Robust, Reliable, Rapid detection

     

PathHunter® Cell-Based Kinase Assays Your Key To Elucidating Novel Kinase Therapeutics

     

Validated GPCR Cell Lines from DiscoveRx for the Corning Epic System!

     

Finally, Include Unactive Kinases in Your Next Screening Campaign - HitHunter® Kinase Binding Assays

     

HitHunter® Kinase Binding Assays

     

PathHunter® Cell-Based Kinase Assay

     

cAMP Hunter™ eXpress GPCR Assays

     

PathHunter® eXpress β-Arrestin GPCR Assays

     

PathHunter® GPCR Internalization Assays

     

ADP Hunter™ and ADP Quest™ Assays for Kinases and ATPases - Screen Compound Libraries and Characterize Hits by Measuring ADP Accumulation

     

ADP Quest™ and ADP Quest™ HS ADP Accumulation Assay for Kinases and ATPases - Single-Well Real Time Kinase and ATPase Kinetics

     

PathHunter® ADAM10 Cell-Based Protease Assay - Functional cell-based assay for screening of ADAM10 activity

     

PathHunter® Homogeneous Mitotic Index Assays

     

LumiLITE™ Microplate Reader

     

Revolutionize GPCR Drug Discovery

     

New & Improved DiscoveRx Calcium No WashPLUS (CaNWPLUS) Assay Kit

     

DiscoveRx Screening & Profiling Services

     

cAMP Hunter™ GPCR Cell Lines

     

Coelenterazine h

     

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User Manuals

Title
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PathHunter® eXpress Receptor Tyrosine Kinase Functional Assay Kit

     

PathHunter® RTK Assay System

     

PathHunter® GPCR Explorer Kit

     

PathHunter® eXpress β-Arrestin Human and Ortholog GPCR Assays

     

PathHunter® eXpress Orphan GPCR β-Arrestin Assays

     

cAMP Hunter™ eXpress GPCR Assays

     

cAMP Hunter™ Gs and Gi Cell Lines

     

PathHunter® Activated GPCR Internalization Assay System User Manual

     

PathHunter® Total GPCR Internalization Assay System User Manual

     

PathHunter® β-Arrestin GPCR Assay System User Manual

     

PathHunter® β-Arrestin Ortholog GPCR Assay System User Manual

     

PathHunter® β-Arrestin Orphan GPCR Assay System User Manual

     

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Presentations

Title
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Small Molecules in Kinase Drug Discovery (Video)

     

Discovery of Novel Biased Ligands: Comparison of 2nd Messenger, β-Arrestin & Internalization Assay Formats

     

Small Molecules in Kinase Drug Discovery (slides)

     

PathHunter® Activated GPCR Internalization Assays

     

PathHunter® Activated GPCR Internalization Assays - FAQ

     

A 30 Minute Tutorial on our PathHunter® Internalization assays

     

Dual Mode PathHunter® β-Arrestin Gq-Coupled Cell Lines

     

The Complex World of β-Arrestin

     

cAMP Hunter™ eXpress GPCR Assays

     

Evaluation of a homogeneous approach for the identification of kinase inhibitors, using β-galactosidase (β-gal)

     

Kinase Compound Profiling at Organon - Organon presentation

     

Right on Target with PathHunter® GPCR & Cell-Based Kinase Assays

     

Mike Weber, Merck (2006), ELRIG: Ultra-High-Throughput Screening for Antagonists of A Gi-Coupled Receptor in A 2.2-ml

     

Veronica Soloveva, Wyeth Research, (2005), LRIG: Fully Automated

     

Priya Kunapulli, Merck (2004), SBS: A Miniaturized 1536-well cAMP assay for

     

PathHunter® eXpress β-Arrestin GPCR Assays

     

Experiences with the DiscoveRx Inositol 1,4,5-trisphosphate Fluoresence Polarization Assay

     

Right on Target with PathHunter™ GPCR & Cell-Based Kinase Assays

     

HTS friendly assays for GPCR internalization

     

Functional GPCR Biosensor Cell Lines

     

Cell-Based Assays for G-Protein independent signaling using Arrestin binding and Endocytosis

     

Ligand-stimulated recruitment of β-Arestin to a non-signaling 7TM decoy receptor

     

Hit Discovery for GPCRs using DiscoveRx PathHunter β-Arrestin assay technology

     

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Application Notes/White Papers

Title
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PathHunter® eXpress β-Arrestin Product Insert

     

Discovery of Novel G-Protein or Arrestin-Biased Ligands Using a Suite of GPCR Signaling Platforms

     

Propelling GPCR drug discovery with innovative products and services

     

Chemiluminescent cAMP Detection Using DiscoveRx HitHunter® Kits Compared With TR-FRET Assays

     

Example Profiling Report

     

Example GPCR and Orphan GPCR Report

     

PathHunter® Receptor Tyrosine Kinase Assays: An Innovative Platform for Identification & Characterization of Functional Antibodies

     

PathHunter® NRF2 Functional Assay
User Manual

     

New PathHunter® eXpress β-Arrestin Assays For Live-Cell GPCR Screening Using The FDSS/RayCatcher

     

Dawn of a New Era for Kinase Drug Discovery: Kinome Wide Profiling and Screening Solutions Coupled to Functional Cell-based Assays Enable Launch of Selective and Functional Kinase Inhibitors

     

DiscoveRx ADP Hunter HS Assay Detects PI-Kinase Activity

     

ADP Quest™ HS kinetic assay with Mithras LB 940

     

DiscoveRx PathHunter® NHR assay for rapid assay results and higher specificity

     

New Momentum for Kinase Drug Discovery

     

PathHunter® NHR Assays

     

Rapid Quantification of Bioactive Ligands in Serum and Human Plasma Using PathHunter® eXpress β-Arrestin GPCR Assays

     

ADP Hunter™ (Plus & HS) and ADP Quest™ (HS) Assay Optimization Checklist and Instrumnet Settings

     

384, Low Volume 384, & 1536-Well ADP Hunter™ HS Assay Protocol & Performance

     

Assay-Ready Live Cell GPCR Assays cAMP Hunter™ & PathHunter® eXpress

     

cAMP Hunter™ eXpress GPCR Assays

     

Evaluation of a new intracellular calcium fluorescent reagent using the FDSS6000

     

Validated, Non-Force Coupled GPCR Cell Lines For Drug Discovery Research

     

Expedite your cAMP screening with reliable, flexible, highly validated assay platform!

     

β-Galactosidase Enzyme Fragment Complementation as a High-Throughput Screening Protease Technology

     

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Posters

Title
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Novel Assays for Pharmacochaperone and Ion Channel Activity Using Enzyme Fragment Complementation

     

A Global Evaluation of Arrestin Binding to 7TM Receptors

     

High Throughput, Quantitative Ligand Binding Assays for Human Bromodomains

     

Novel Assays for Pharmacochaperone and Ion Channel Activity Using Enzyme Fragment Complementation

     

Comprehensive analysis of kinase inhibitor selectivity

     

Utilization of PathHunter® Pathway assays for siRNA applications

     

HitHunter® cAMP and cAMP Hunter™ Cell Line: Your Solution for Use with High Serum Samples, Difficult Gi Targets and Identification of Allosteric Modulators

     

Rapid Quantification of Bioactive Ligands in Serum and Human Plasma Using PathHunter® eXpress β-Arrestin GPCR Assays

     

Identification and Characterization of Novel GPCR Heterodimer Pairs Using the PathHunter® eXpress Assay System

     

Functional Receptor Tyrosine Kinase Assays for Antibody Therapeutics Using PathHunter? Technology

     

Functional Whole-cell Assays for Tyrosine Phosphorylation Using PathHunter® Technology

     

New Cell-Based Kinase Assays for TrkA and Other Receptor tyrosine Kinases using PathHunter® Protein-Protein Interaction Technology

     

A High Sensitivity Assay for Kinetic Analysis of Kinases and ATPases Based on Measurement of ADP Accumulation

     

Cell-Based Assays for G-Protein Independent Signaling Using Arrestin Binding and Endocytosis

     

PathHunter® Pathway Assays: Cell-Based Assay tool for Cell Signaling

     

The Development of a Universal, HTS-Compatible Platform for Monitoring Receptor Internalization

     

Interrogate Your Compounds for Ligand Bias with a Suite of PathHunter® and HitHunter® GPCR Screening Platforms

     

The Development of a Universal, HTS-Compatible Platform for Monitoring Receptor Internalization

     

Interrogate Your Compounds for Ligand Bias with a Suite of PathHunter® and HitHunter® GPCR Screening Platforms

     

Applications of EFC-based Protein-Protein Interaction Assays for GPCR Screening, SBS 2007

     

Optimized ADP Accumulation Assays for PI-3 Kinase for Primary Screening, Kinase and Kinase Inhibitor Characterization

     

Miniaturization friendly cAMP - One-step detection assay using enzyme fragment complementation technology

     

Functional Assays for GPCR Heterodimerization using PathHunter® β-Arrestin Assays

     

PathHunter® eXpress β-Arrestin Bioassays: Novel Detection of Functional Therapeutic Antibodies

     

PathHunter® β-Arrestin Assays as a Universal Tool For Orphan GPCR Analysis

     

PathHunter® eXpress: Development of a Single-Use Cell-Based Functional GPCR Assay Kit

     

Application of the PathHunter® Protein Interaction Assay to Receptor Tyrosine Kinases (RTKs): Developing a Non-Antibody One-Step Cell_Based Kinase Activity

     

Comparison of HTRF and HitHunter® cAMP Assay Technologies for HTS

     

An Improved Enzyme Fragment Complementation (EFC) Technology for Detection of cAMP in Miniaturised and Automated uHTS

     

Novel Assay Platforms for Orphan GPCR High Throughput Screening

     

Functional, Cell-Based Pathway Assays Using PathHunter® Technology

     

Which Assay Is Most Appropriate To Understand The Pharmacology Of A Ligand And How It Translates Through To Ex-vivo Tissue Bath Studies - A Case Study Using the Mu Opioid Receptor

     

cAMP Detection Using Enzyme Fragment Complementation (EFC) Technology for Detection of cAMP in Miniaturised and Automated uHTS

     

Unique Properties of PathHunter® β-Arrestin Assays for GPCR Antagonist Discovery and Characterization

     

ADP Quest™ and ADP Quest™ HS: Universal AdP Accumulation Assay for Enzyme Kinetics

     

HitHunter® cAMP and cAMP Hunter™ Cell Line: Your Solution for Use with High Serum Samples, Difficult Gi Targets and Identification of Allosteric Modulators

     

A Wide Range of Compound Efficacies Revealed Using PathHunter® Arrestin Assays

     

PathHunter® β-Arrestin Assays: Determination of Pharmacology Differences Between Human and Ortholog GPCRs

     

PathHunter® Cell-Based Kinase Assays: A Portfolio of HTS-friendly Cytoplasmic or Receptor Tyrosine Kinase Assays for Small Molecule Inhibitors as well as Monoclonal Antibodies

     

Utilization of PathHunter® Arrestin Cell Lines for Detection of Arrestin Biased Ligands and Compound Pharmacology Distinct from Second Messengers

     

β-Arrestin translocation EFC assay evaluation: GPCR Chemokine Antagonists assay

     

Use of HitHunter® cAMP Screening in the Discovery of Agonists for a Gi Coupled GPCR

     

PathHunter® NHR Protein Interaction Cell Lines: Study Nuclear Hormone Receptors Without Using Reporter Gene Assays

     

Homogeneous Assays for Nuclear Hormone Receptors Using Enzyme Fragment Complementation

     

Profiling for GPCR activation using DiscoveRx PathHunter® β-Arrestin technology

     

PathHunter® β-Arrestin Assays as a Universal Tool for Orphan GPCR Analysis

     

Arrestin-Based GPCR Analysis - Insights on Biased Ligands, Allosteric Modulators and Compound Pharmacology Compared to Traditional GPCR Assays

     

Development of a Panel of cAMP Hunter™ Cell Lines for Analysis of Naturally Coupled GPCRs Using the DiscoveRx

     

Utilization of PathHunter® Arrestin Cell Lines for Detection of Arrestin Biased Ligands and Compound Pharmacology

     

Profiling for GPCR activation using DiscoveRx PathHunter®
β-Arrestin technology

     

Arrestin-Based GPCR Analysis - Insights on Biased Ligands, Allosteric Modulators and Compound Pharmacology Compared to Traditional GPCR Assays

     

Dual Purpose Cell Lines for Analysis of GPCR/Arrestin Interaction using PathHunter® and Natural Gq-Coupling Using the Improved Calcium No-WashPLUS (CaNWPLUS) Kit

     

Utilization of PathHunter® Arrestin Cell Lines for Detection of Arrestin Biased Ligands and Compound Pharmacology Distinct from Second Messengers

     

ADP Hunter™ Plus: A Rapid, Quantitative HTS Assay for GDP and UDP

     

ADP Hunter™ HS and Quest™ HS: Improved ADP accumulation assays for kinase primary screening and inhibitor characterization/lead optimization

     

A Technique Using β-galactosidase Enzyme Fragment Complementation to Directly Characterize Inhibitor Binding to Active and Unactive Kinases

     

HitHunter® cAMP Assays: Versatile Assays Validated for Multiple Applications

     

Miniaturization of the HitHunter® cAMP XS+ Assay for Gs/Gi Screening in 1536-well Plate

     

DiscoveRx HitHunter® Enzyme Fragment Complementation Chemiluminescence Assay for the Detection of cAMP Production from Membranes and Whole Cells for GPCRs

     

A New High-Throughput Screening Platform for p38-MAP Kinase Inhibitors in a Kinase Binding Mode

     

The Druggable GPCRome

     

The Druggable GPCRome

     

A Homogeneous Assay to Monitor Cellular Mitosis using β-Galactosidase Complementation

     

A Novel Method to Detect Proteases Utilizing Complementation of Enzyme Fragments as a Signal Generation System

     

Development of a Panel of Chemiluminescence-based Protease Probes for Matrix Metalloprotease

     

Development of High Sensitivity and Selectivity Probes for Protease HTS Assays

     

Measuring GPCR Activation: Novel Homogenous Assay for Inositol (1,4,5) Trisphosphate

     

An Evaluation of an Inositol 1,4,5-trisphosphate Fluoresence Polarization Assay for Measuring Activation of Gq-coupled Receptors

     

A Comparison of Fluorescence Polarisation and AlphaScreen Assays for the Measurement of Intracellular Inositol 1,4,5-trisphosphate

     

The Druggable GPCRome

     

A Novel Calcium No Wash Assay for Analyisis of GPCR Signaling

     

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Bibliography

Title
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PathHunter® β-Arrestin Select References

     

HitHunter® cAMP Select References

     

 

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