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Kinases

- The Broadest Panel of Kinase Solutions for Characterization and Screening

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PathHunter^® Cell-Based Kinase Assays

DiscoveRx offers the most comprehensive portfolio of solutions for kinase drug discovery including a rapidly expanding panel of PathHunter® cell-based kinase assays for high value kinase targets in Oncology, CNS, metabolic disorders and inflammation. Screen or profile your inhibitors against kinase targets in a cellular context using simple, single-addition chemiluminescent detection. Study receptor tyrosine kinase activation, RTK internalization and other cytosolic kinases using functional cell-based assays. Fully optimized, target-validated cell lines and off-the-shelf kits provide you convenience, relevant hits and guaranteed performance for screening, profiling or research applications

Product Features

Target-specific functional cell-based assay
Full Length receptor or cytosolic protein enables you to also detect allosteric
modulators as well as biological therapeutics
Direct measure of kinase activation, phosphorylation and interaction with SH2
domain containing proteins
Ready-to-screen biosensor cell lines or Assay-ready frozen cells are available
One-step, HTS-ready, miniaturizable assay

Applications

Discover functional antibodies
Detect biologically relevant inhibitors against ATP binding domain as well as
ligand binding domain
Differentiate potencies and selectivity of your lead compound or lead series

For instrument compatibility, please click here.

How does the assay work?

Click here to view assay principle

Discover, Detect and Differentiate small molecule inhibitors as well as functional antibodies

Available Literature

Click here to view what we have available!

Clonal Cell Lines

PathHunter® Receptor Tyrosine Kinase Assays

Unique, whole cell assay platform for screening and profiling of select receptor tyrosine kinases; Over 25 ready-to-screen biosensor cell lines are now available. READ MORE»

PathHunter® Cytosolic Tyrosine Kinase Assays

Measure cytokine receptor activation and inhibition of cytosolic tyrosine kinases; Choose your HTS-ready JAK assays. READ MORE»

PathHunter® Pathway Assays

Novel, non-imaging, ready-to-screen, biosensor cell lines allows you to study downstream kinases in a cellular context. READ MORE»

Assay-Ready Formats

PathHunter® eXpress Receptor Tyrosine Kinase Functional Assays

Discover antibodies, advance leads, confirm hits with ready-to-assay receptor tyrosine kinase kits. READ MORE»

PathHunter® eXpress Cytoplasmic Tyrosine kinase assays

Thaw..Plate..Read; Functional whole-cell tyrosine kinase assays in less than a day. READ MORE»

PathHunter® eXpress Pathway Assays

Choose your complete, convenient, cell-based assay kits that includes
pre-validated cells, ligands and reagents. READ MORE»

Companion Products

PathHunter® Detection Reagents

Chemiluminescent detection reagents for use with all PathHunter cell-based kinase cell Lines. Kits available for either Glow or Flash luminescence.
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PathHunter® Certified Reagents

No more assay development required! Pre-validated PathHunter® Certified Reagents include high quality ligands and cell plating reagents. READ MORE»

You can access our technology in a variety of convenient formats including validated clonal cell lines, assay-ready products, or parental cell lines and expression vectors to support your in-house kinase drug discovery. If you want our experts to work for you, we also offer custom assay development as well as screening and profiling services.