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Kinases

– Universal Assays for Kinase Screening

Activity-Based Universal Assay Literature

Flyers/Brochures

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Title
Technology
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The Broadest Panel of Kinase Solutions
for Characterization, Profiling & Screening
PathHunter® Kinase Overview
ADP Hunter™ and ADP Quest™ Assays for Kinases
and ATPases - Screen Compound Libraries and Characterize Hits by Measuring ADP Accumulation
ADP Hunter™ and ADP Quest™ Assays
ADP Quest™ and ADP Quest™ HS ADP Accumulation Assay for Kinases and ATPases - Single-Well Real Time Kinase and ATPase Kinetics
ADP Quest™ Assays
ADP Hunter™ (Plus & HS) and ADP Quest™ (HS)
Assay Optimization Checklist and Instrumnet Settings
ADP Hunter™ and ADP Quest™ Assays

Posters

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Title
Technology
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ADP Quest™ and ADP Quest™ HS: Universal
ADP Accumulation Assay for Enzyme Kinetics
ADP Quest™ & ADP Quest™ HS,
SBS 2010
Optimized ADP Accumulation Assays for PI-3
Kinase for Primary Screening, Kinase and Kinase
Inhibitor Characterization
ADP Hunter™ HS Assays, AACR 2008
ADP Hunter™ Plus: A Rapid, Quantitative HTS
Assay for GDP and UDP
ADP Hunter™ Plus Assays, SBS 2008
A High Sensitivity Assay for Kinetic Analysis of
Kinases and ATPases Based on Measurement of
ADP Accumulation
ADP Quest™ Assays, AACR 2007
ADP Hunter™ HS and Quest™ HS: Improved ADP
accumulation assays for kinase primary screening
and inhibitor characterization/lead optimization
ADP Hunter™ HS ADP Quest™ HS Assays, SBS 2007

Application Notes

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Title
Technology
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384, Low Volume 384, and 1536-Well ADP Hunter™
HS Assay Protocol and Performance
ADP Hunter™ HS Assay
ADP Quest™ HS kinetic assay with Mithras LB 940
ADP Quest™ Assays
DiscoveRx's ADP Hunter HS Assay Detects PI3-Kinase Activity in a Highly-Sensitive, Gain-of-Signal HTS Assay
Kinase Assay

Bibliography

Title
1. Katja Kristan, Miha Kotnik , Marko Oblak , Uro Urleb J Biomol Screen (2009) ,New High-Throughput
    Fluorimetric Assay for Discovering Inhibitors of UDP-N-Acetylmuramyl-l-Alanine: d-Glutamate (MurD)
    Ligase, 14, (4), 412-418
2. Xudong Huang, Patrick Finerty Jr. John R. Walker, Christine Butler-Cole Masoud Vedadi, Matthieu
    SchapiraSirlester A. Parker, Benjamin E. TurkDebra A. Thompson and Sirano Dhe-Paganon, J. Struct Biol .
    (2009), Structural insights into the inhibited states of the Mer receptor tyrosine kinase, 165 (2), 88-96
3. Charter NW, Kauffman L, Singh R, Eglen RM., J Biomol Screen (2006), A Generic, Homogenous Method for
    Measuring Kinase and Inhibitor Activity via Adenosine 5'-Diphosphate Accumulation, 11(4), 390-399
4. Zhang B, Senator D, Wilson CJ, Ng SC. Anal Biochem (2005), Development of a high-throughput robotic
    fluorescence-based assay for HsEg5 inhibitor screening , 345 (2), 326-335
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