Biological Information | |
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Background Information: | Hematopoietic cell kinase (HCK) is a member of Src protein-tyrosine kinase family and expressed primary in granulocytes, monocytes and macrophages. Active HCK phosphorylates STAT5B on Tyr699, which represents an essential step in Signal transducer and activator of transcription 5 (STAT5B) stimulation. The binding of SH3 ligands, such as the Nef protein of HIV-1, further augments Hck activity suggesting a new mechanism for regulating tyrosine kinase activity.
GenBank NM_002110 |
Target Class: | Kinase |
Family: | Cytosolic Tyrosine Kinase |
Accession Number: | NM_002110.2 |
Target Name: | Hck |
Target Aliases: | HCK, p59-HCK/p60-HCK, JTK9 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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