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GPCR Cell Line Target List

 

Family Common
 Name		 GPCR Gene Coupling PathHunter®
 β-Arrestin		 PathHunter®
 eXpress		 EasyScreen™
 β-Arrestin		 Second
 Messenger		 cAMP Hunter™
 eXpress		 Calcium
 Cell Lines		 Internalization
VIP & PACAP PAC1 ADCYAP1R1 Gs & Gq human mouse human mouse human mouse human human   human
Adenosine A1 ADORA1 Gi human   human   human   human      
Adenosine A2A ADORA2A Gq               human human  
Adenosine A2B ADORA2B Gs human mouse   mouse   mouse human human    
Adenosine A3 ADORA3 Gi human mouse human   human   human      
Adrenoreceptor a1A ADRA1A Gq human                 human
Adrenoreceptor a1B ADRA1B Gq human mouse human   human          
Adrenoreceptor a2A ADRA2A Gi human   human   human   human      
Adrenoreceptor a2B ADRA2B Gi human   human   human          
Adrenoreceptor a2C ADRA2C Gi human   human   human   human human    
Adrenoreceptor B1AR ADRB1 Gs human   human   human   human      
Adrenoreceptor B2AR ADRB2 Gs human   human   human   human human   human
Adrenoreceptor B3AR ADRB3 Gs             human      
Angiotensin AT1 AGTR1 Gi & Gq human   human   human          
Apelin APJ AGTRL1 Gi human mouse human   human   human     human
Vasopressin V1A AVPR1A Gq human   human   human          
Vasopressin V1B AVPR1B Gq human   human   human         human
Vasopressin V2 AVPR2 Gs human mouse human   human   human     human
Bradykinin B1 BDKRB1 Gi & Gq human   human   human       human  
Bradykinin B2 BDKRB2 Gq human   human   human         human
Bombesin BB3 BRS3 Gq human mouse human   human       human  
Anaphylotoxin C3A C3AR1 Gi human           human     human
Anaphylotoxin GPR77 C5L2   human   human   human         human
Anaphylotoxin C5A C5R1 Gi human mouse human mouse human mouse human human   human
Calcitonin CT CALCR Gs human   human   human   human      
Calcitonin AMY2 CALCR + RAMP2 Gs human   human   human          
Calcitonin AMY3 CALCR + RAMP3 Gs human   human   human   human      
Calcitonin CGRP1 CALCRL + RAMP1 Gs human   human   human   human      
Calcitonin AM1 CALCRL + RAMP2 Gs human   human   human          
Calcitonin AM2 CALCRL + RAMP3 Gs human   human   human   human      
Cholecystokinin CCK1 CCKAR Gq human mouse human   human         human
Cholecystokinin CCK2 CCKBR Gq human   human   human         human
Chemokine CCR1 CCR1 Gi human mouse         human     human
Chemokine CCR2 CCR2 Gi human mouse human mouse human         human
Chemokine CCR3 CCR3 Gi human mouse human mouse            
Chemokine CCR4 CCR4 Gi human mouse human mouse human mouse        
Chemokine CCR5 CCR5 Gi human mouse human mouse human mouse human     human
Chemokine CCR6 CCR6 Gi human mouse human mouse human mouse human human   human
Chemokine CCR7 CCR7 Gi human mouse human mouse     human human   human
Chemokine CCR8 CCR8 Gi human mouse human   human         human
Chemokine CCR9 CCR9 Gi human mouse human   human          
Chemokine CCR10 CCR10 Gi human mouse human   human   human     human
Acetylcholine M1 CHRM1 Gq human   human   human         human
Acetylcholine M2 CHRM2 Gi human   human   human   human human   human
Acetylcholine M3 CHRM3 Gq human   human   human         human
Acetylcholine M4 CHRM4 Gi human   human   human   human      
Acetylcholine M5 CHRM5 Gq human   human   human         human
Chemokine Chem23 CMKLR1 Gi human mouse human mouse human mouse human human   human
Chemokine CXCR7 CMKOR1 Gi human mouse human mouse human         human
Cannabinoid CB1 CNR1 Gi human mouse human mouse human mouse human human   human
Cannabinoid CB2 CNR2 Gi human mouse   mouse   mouse human human    
Corticotropin CRF1 CRHR1 Gs human mouse human mouse human mouse human human   human
Corticotropin CRF2 CRHR2 Gs human   human   human   human human    
Prostanoid DP2 CRTH2 Gi human mouse,
rat		 human rat human rat human      
Chemokine CX3CR1 CX3CR1 Gi human mouse human   human          
Chemokine CXCR3 CXCR3 Gi human mouse human mouse human   human human   human
Chemokine CXCR4 CXCR4 Gi human mouse         human human    
Chemokine CXCR5 CXCR5 Gi human mouse human mouse human mouse human human    
Chemokine CXCR6 CXCR6 Gi human mouse human mouse   mouse human     human
Leukotriene LTC4 CYSLTR2 Gq                 human  
Dopamine D1 DRD1 Gs human rat human   human   human, rat human, rat   human
Dopamine D2 DRD2 Gi human rat human   human   human, rat human    
Dopamine D3 DRD3 Gi human   human   human          
Dopamine D4 DRD4 Gi human           human      
Dopamine D5 DRD5 Gs human mouse,
rat		 human   human   human human    
Lysophospholipid S1P1 EDG1 Gi human mouse human mouse human   human     human
Lysophospholipid LPA1 EDG2 Gi human           human      
Lysophospholipid S1P3 EDG3 Gi human   human   human       human human
Lysophospholipid LPA2 EDG4 Gi human   human   human       human  
Lysophospholipid S1P2 EDG5 Gs human mouse,
canine,
rat,
simian		 human   human         human
Lysophospholipid S1P4 EDG6 Gi human mouse                
Lysophospholipid LPA3 EDG7 Gi & Gq human                 human
Lysophospholipid S1P5 EDG8 Gi human                  
Endothelin ETA EDNRA Gq human mouse human mouse human mouse        
Endothelin ETB EDNRB Gi, Gs, & Gq human mouse human mouse human mouse   human    
Protease activated PAR1 F2R Gi human   human   human          
Protease activated PAR2 F2RL1 Gi & Gq human   human   human       human human
Protease activated PAR4 F2RL3 Gi & Gq human   human   human         human
Formylpeptide FPR FPR1 Gq human mouse human   human   human      
Formylpeptide ALX FPRL1 Gi human   human   human   human human   human
Glycoprotein
 Hormone Receptor		 FSH FSHR Gs human   human       human      
Galanin GAL1 GALR1 Gi human mouse human   human   human human   human
Galanin GAL2 GALR2 Gi human mouse   mouse   mouse human   human human
Glucagon Glucagon GCGR Gs human mouse human   human   human human   human
Glucagon GHRH GHRHR Gs             human human    
Ghrelin GRLN GHSR1a Gq human mouse human mouse human mouse        
Glucagon GIP GIPR Gs human   human   human   human, mouse human, mouse   human
Glucagon GLP-1 GLP1R Gs human mouse human mouse human mouse human human   human
Glucagon GLP-2 GLP2R Gs human   human   human   human human   human
Gonadotrophin-releasing
 Hormone Receptor		 GnRH GNRHR Gq/11, Gi/Go                 human  
Bile Acid Receptors GPR131 GPBAR1 Gs human           human human    
Class A Orphan GPR1 GPR1   human mouse human   human         human
Class A Orphan GPR35 GPR35   human   human   human   human human    
Class A Orphan GPR39 GPR39 Gq                 human  
Free Fatty Acid FFAR1 GPR40 Gq/11, Gs human               human  
Free Fatty Acid FFAR3 GPR41 Gi/Go             human      
Free Fatty Acid FFAR2 GPR43 Gq                 human  
Class A Orphan GPR55 GPR55   human   human   human          
Class A Orphan GPR81 GPR81   human           human      
Class A Orphan GPR84 GPR84 Gi human           human      
Succinate Receptor SUCNR1 GPR91   human mouse                
Class A Orphan GPR92 GPR92   human   human   human          
Nicotinic Acid HM74A GPR109A Gi human   human   human   human      
Nicotinic Acid N/A GPR109B Gi human           human human    
Class A Orphan GPR119 GPR119   human                  
Class A Orphan GPR120 GPR120   human   human   human         human
Glutamate mGlu2 GRM2 Gi             human      
Glutamate mGLU3 GRM3 Gi/Go             human      
Glutamate mGlu4 GRM4 Gi             human human    
Glutamate mGlu6 GRM6 Gi             human human    
Bombesin BB2 GRPR Gq human   human   human         human
Orexin OX1 HCRTR1 Gq human mouse human   human         human
Orexin OX2 HCRTR2 Gq human   human   human         human
Histamine H1 HRH1 Gq human   human   human          
Histamine H2 HRH2 Gs human   human   human   human human    
Histamine H3 HRH3 Gi human   human   human   human human    
Histamine H4 HRH4 Gi human                  
Serotonin 5HT6 HT6 Gq human                  
Serotonin 5HT1A HTR1A Gi human   human   human   human      
Serotonin 5HT1B HTR1B Gi human   human   human   human      
Serotonin 5HT1E HTR1E Gi human                  
Serotonin 5HT1F HTR1F Gi human   human   human   human      
Serotonin 5HT2A HTR2A Gi human mouse human   human         human
Serotonin 5HT2B HTR2B Gq human                  
Serotonin 5HT2C HTR2C Gq human mouse human   human         human
Serotonin 5HT5A HTR5A Gi, Gq human           human      
Serotonin 5HT7A HTR7A Gs             human      
Serotonin 5HT7B HTR7B Gs             human      
Serotonin 5HT7D HTR7D Gs             human      
Chemokine CXCR1 IL8RA (CXCR1) Gi human   human   human   human human   human
Chemokine CXCR2 IL8RB (CXCR2) Gi human mouse human mouse human mouse human human   human
KISS1-derived
 Peptide Receptor		 GPR54 KISS1R Gq human mouse human   human          
Luteneizing Hormone LH LHCGR Gs human           human human    
Lukotriene BLT1 LTB4R Gi & Gq human mouse human   human   human human   human
Melanocortin MC1 MC1R Gs human   human   human   human      
Melanocortin MC3 MC3R Gs human mouse human   human   human human    
Melanocortin MC4 MC4R Gs human mouse human       human human    
Melanocortin MC5 MC5R Gs human mouse human       human      
Melanin-Concentrating
 Hormone Receptor		 MCH1 MCHR1 Gi human mouse         human human    
Melanin-Concentrating
 Hormone Receptor		 MCH2 MCHR2 Gq human   human   human          
Motilin motilin MLNR Gq human   human   human         human
Class A Orphan MRGX2 MRGPRX2 Gq human   human   human          
Melatonin MT1 MTNR1A Gi & Gq human   human   human   human human    
Melatonin MT2 MTNR1B Gi human   human   human   human human    
Neuromedin U NMU1 NMU1R Gq human   human   human         human
Neuropeptide B & W GPR7 NPBWR1 Gi human   human   human   human      
Neuropeptide B & W GPR8 NPBWR2 Gi human   human   human   human      
Neuropeptide F GPR147 NPFFR1 Gi human           human human    
Neuropeptide F GPR74 NPFFR2 Gi             human human    
Neuropeptide S NPS NPSR1 Gq & Gs human                  
Neuropeptide Y Y1 NPY1R Gi human mouse human   human   human      
Neuropeptide Y Y2 NPY2R Gi human mouse human   human   human human   human
Neurotensin NTS1 NTSR1 Gq human   human   human         human
Opioid δ OPRD1 Gi human mouse human mouse human mouse human human   human
Opioid κ OPRK1 Gi human mouse   mouse   mouse human human    
Opioid NOP OPRL1 Gi human   human   human   human human    
Opioid m OPRM1 Gi human mouse,
rat		 human mouse,
  rat		 human mouse,
  rat		 human     human
Eicosanoid receptor GPR170 OXER1 Gi             human human    
Class A Orphan GPR99 OXGR1 Gq                 human  
Vasopressin OT OXTR Gi & Gq human mouse human   human         human
P2Y P2Y1 P2RY1 Gq                 human  
P2Y P2Y2 P2RY2 Gq human   human   human         human
P2Y P2Y4 P2RY4 Gq human   human   human         human
P2Y P2Y6 P2RY6 Gq human mouse                
P2Y P2Y11 P2RY11 Gs & Gq human   human   human         human
P2Y P2Y12 P2RY12 Gi human mouse human mouse human mouse        
Neuropeptide Y Y4 PPYR1 (NPY4R) Gi human mouse human   human   human human    
Prolactin Releasing
 Peptide Receptor		 PRRP PRLHR Gq human   human   human         human
Prokineticin PKR1/GPR73 PROKR1 Gq & Gs human rat human rat human rat human human    
Prokineticin PKR2 PROKR2 Gs human rat human rat human         human
Platelet-activating
 factor		 PAF PTAFR Gi & Gq human mouse human mouse human mouse human     human
Prostanoid DP1 PTGDR Gs             human human    
Prostanoid EP1 PTGER1 Gq/11, Gi/Go                 human  
Prostanoid EP2 PTGER2 Gs human   human   human          
Prostanoid EP3 PTGER3 Gi human   human   human   human human    
Prostanoid EP4 PTGER4 Gq human   human   human          
Prostanoid FP PTGFR Gq                 human  
Prostanoid IP1 PTGIR Gs human mouse         human human    
PTH receptor PTH1 PTHR1 Gs human   human   human   human human   human
PTH receptor PTH2 PTHR2 Gs human   human   human   human human   human
Relaxin LGR7 RXFP1 Gs             human human    
Relaxin LGR8 RXFP2 Gs             human      
Relaxin SALPR RXFP3 Gi human   human       human human    
Relaxin RXFP4 RXFP4 Gi human           human      
Secretin SEC SCTR Gs human   human   human   human human   human
Somatostatin SST1 SSTR1 Gi human   human              
Somatostatin SST2 SSTR2 Gi human mouse human   human   human human   human
Somatostatin SST3 SSTR3 Gi human   human   human   human      
Somatostatin SST4 SSTR4 Gi human   human   human   human human    
Somatostatin SST5 SSTR5 Gi human mouse human   human   human      
Tachykinin NK1 TACR1 Gs human mouse human   human         human
Tachykinin NK2 TACR2 Gs & Gq human   human   human         human
Tachykinin NK3 TACR3 Gs human   human   human   human human   human
Prostanoid TP TBXA2R Gq human   human   human          
TRH TRH TRHR Gq human   human   human          
Glycoprotein
 Hormone Receptor		 TSH TSHR(L) Gs human           human      
Urotensin UT UTR2 Gq human mouse human mouse human mouse       human
VIP & PACAP VPAC1 VIPR1 Gs human mouse human mouse human mouse human human   human
VIP & PACAP VPAC2 VIPR2 Gs human   human   human   human human   human
Chemokine XC1 XCR1 Gi human           human      

 

 

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