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- GPCR Counterscreening Made Easy
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PathHunter® β-Arrestin GPCR Literature

Brochures/Flyers

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Dual Mode PathHunter® β-Arrestin GPCR Cell Lines
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PathHunter® β-Arrestin Assays Universal Asssay for Virtually Any GPCR
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Revolutionize GPCR Drug Discovery
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User Manuals

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PathHunter® β-Arrestin GPCR Assay System User Manual

     

PathHunter® β-Arrestin Ortholog GPCR Assay System User Manual

     

PathHunter® β-Arrestin Orphan GPCR Assay System User Manual

     

Presentations

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Discovery of Novel Biased Ligands: Comparison of 2nd Messenger, β-Arrestin & Internalization Assay Formats
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Dual Mode PathHunter® β-Arrestin Gq-Coupled Cell Lines
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The Complex World of β-Arrestin
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Right on Target with PathHunter™ GPCR & Cell-Based Kinase Assays
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HTS friendly assays for GPCR internalization
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Cell-Based Assays for G-Protein independent signaling using Arrestin binding and Endocytosis
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Ligand-stimulated recruitment of β-Arestin to a non-signaling 7TM decoy receptor
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Hit Discovery for GPCRs using DiscoveRx PathHunter β-Arrestin assay technology
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Application Notes/White Papers/Booklets

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Discovery of Novel G-Protein or Arrestin-Biased Ligands Using a Suite of GPCR Signaling Platforms
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Propelling GPCR drug discovery with innovative products and services
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Posters

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A Global Evaluation of Arrestin Binding to 7TM Receptors
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Interrogate Your Compounds for Ligand Bias with a Suite of PathHunter® and HitHunter® GPCR Screening Platforms
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Applications of EFC-based Protein-Protein Interaction Assays for GPCR Screening, SBS 2007
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Functional Assays for GPCR Heterodimerization using PathHunter® β-Arrestin Assays
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PathHunter® β-Arrestin Assays as a Universal Tool For Orphan GPCR Analysis
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Which Assay Is Most Appropriate To Understand The Pharmacology Of A Ligand And How It Translates Through To Ex-vivo Tissue Bath Studies - A Case Study Using the Mu Opioid Receptor
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Unique Properties of PathHunter® β-Arrestin Assays for GPCR Antagonist Discovery and Characterization
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A Wide Range of Compound Efficacies Revealed Using PathHunter® Arrestin Assays
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PathHunter® β-Arrestin Assays: Determination of Pharmacology Differences Between Human and Ortholog GPCRs
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Utilization of PathHunter® Arrestin Cell Lines for Detection of Arrestin Biased Ligands and Compound Pharmacology Distinct from Second Messengers
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β-Arrestin translocation EFC assay evaluation: GPCR Chemokine Antagonists assay
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The Druggable GPCRome
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Bibliography

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PathHunter® β-Arrestin Select References
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Zhao, X et al. (2008). A homogeneous enzyme fragment complementation-based β-Arrestin translocation assay for high-throughput screening of G-protein-Coupled receptors. J Biomol Screen. 13(8):737-747. (SSTR2)
Gao, Z-G and Jacobson, KA (2008). Translocation of arrestin induced by human A3 adenosine receptor ligands in a engineered cell line: comparison with G protein-dependent pathways. Pharma Res. 57:303-311. (ADORA3)
Van de Lee, MMC et al (2008). β-Arrestin recruitment assay for the identification of agonists of the sphingosine 1-phosphate receptor EDG1. J Biomol Screen. 13(10): 986-998. (EDG1)
McGuinness, D, et al. (2009) Characterizing Cannabinoid CB2 Receptor Ligands using DiscoveRx PathHunter® Assay. J Biol Chem. 284(18):12328-12338 (ProLink Cloning Vector and HEK 293 EA-Arrestin Parental Cell Line)

 

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