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List of Targets

 
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GPCRs          GPCR Orphans         Kinases         NHRs         Pathways         Proteases

 

GPCRs
Family Common
Name		 GPCR Gene Coupling PathHunter® β-Arrestin cAMP Hunter™ Calcium
Cell Lines		 Internalization Available
as Service
Cell Line eXpress Cell Line eXpress Cell Line eXpress
VIP & PACAP PAC1 ADCYAP1R1 Gs & Gq human mouse human mouse human human human √
Adenosine A1 ADORA1 Gi human
human		 human √
Adenosine A2A ADORA2A Gq human √
Adenosine A2B ADORA2B Gs human mouse mouse human human √
Adenosine A3 ADORA3 Gi human mouse human human √
Adrenoreceptor A1a ADRA1A Gq human human √
Adrenoreceptor a1B ADRA1B Gq human mouse human √
Adrenoreceptor a2A ADRA2A Gi human human human human √
Adrenoreceptor a2B ADRA2B Gi human human √
Adrenoreceptor a2C ADRA2C Gi human human human human √
Adrenoreceptor B1AR ADRB1 Gs human human human human √
Adrenoreceptor B2AR ADRB2 Gs human human human human human human √
Adrenoreceptor B3AR ADRB3 Gs human √
Angiotensin AT1 AGTR1 Gi & Gq human
human		 human √
Apelin APJ AGTRL1 Gi human
human		 mouse human human human human √
Vasopressin V1A AVPR1A Gq human human human √
Vasopressin V1B AVPR1B Gq human
human		 human human human √
Vasopressin V2 AVPR2 Gs human
human		 mouse human human human √
Bradykinin B1 BDKRB1 Gi & Gq human human human √
Bradykinin B2 BDKRB2 Gq human
human		 human human √
Bombesin BB3 BRS3 Gq human mouse human human √
Anaphylotoxin C3A C3AR1 Gi human human human √
Anaphylotoxin C5A C5AR1 Gi human mouse human mouse human human human human √
Anaphylotoxin GPR77 C5L2 N/A human human human √
Calcitonin CT CALCR Gs human
human		 human human √
Calcitonin AMY1 CALCR+RAMP1 Gs human √
Calcitonin AMY2 CALCR+RAMP2 Gs human human √
Calcitonin AMY3 CALCR+RAMP3 Gs human human human √
Calcitonin CGRP1 CALCRL+RAMP1 Gs human human human √
Calcitonin AM1 CALCRL+RAMP2 Gs human human human √
Calcitonin AM2 CALCRL+RAMP3 Gs human human human √
Cholecystokinin CCK1 CCKAR Gq human
human		 mouse human human human √
Cholecystokinin CCK2 CCKBR Gq human human human √
Chemokine CCR1 CCR1 Gi human
human		 mouse human human human √
Chemokine CCR2 CCR2 Gi human
human		 mouse human mouse human human √
Chemokine CCR3 CCR3 Gi human mouse human mouse √
Chemokine CCR4 CCR4 Gi human mouse human mouse human human √
Chemokine CCR5 CCR5 Gi human mouse human mouse human
human		 human √
Chemokine CCR6 CCR6 Gi human mouse human human human human human √
Chemokine CCR7 CCR7 Gi human
human		 mouse human
human		 mouse human human human √
Chemokine CCR8 CCR8 Gi human mouse human human √
Chemokine CCR9 CCR9 Gi human mouse human √
Chemokine CCR10 CCR10 Gi human mouse human human
human		 human human √
Acetylcholine M1 CHRM1 Gq human human human √
Acetylcholine M2 CHRM2 Gi human human human human human human √
Acetylcholine M3 CHRM3 Gq human human human human √
Acetylcholine M4 CHRM4 Gi human rat human human √
Acetylcholine M5 CHRM5 Gq human human human human √
Chemokine Chem23 CMKLR1 Gi human mouse human mouse human human human √
Cannabinoid CB1 CNR1 Gi human mouse human mouse human human √
Cannabinoid CB2 CNR2 Gi human
human		 mouse mouse human human √
Corticotropin CRF1 CRHR1 Gs human mouse human mouse human human human √
Corticotropin CRF2 CRHR2 Gs human human human human √
Prostanoid DP2 CRTH2 Gi human
human		 mouse
rat		 human rat human √
Chemokine CX3CR1 CX3CR1 Gi human mouse human √
Chemokine CXCR1 CXCR1(IL8RA) Gi human human human human human √
Chemokine CXCR2 CXCR2(IL8RB) Gi human
human		 mouse human
human		 mouse human human human √
Chemokine CXCR3 CXCR3 Gi human
human		 mouse human human human human human √
Chemokine CXCR4 CXCR4 Gi human mouse human human √
Chemokine CXCR5 CXCR5 Gi human
human		 mouse human
human		 mouse human human √
Chemokine CXCR6 CXCR6 Gi human
human		 mouse human mouse human human human √
Chemokine CMKOR1 CXCR7 N/A human mouse human mouse human human √
Leukotriene LTC4 CYSLTR2 Gq human √
Dopamine D1 DRD1 Gs human rat human human
rat		 human
rat		 human √
Dopamine D2 DRD2(S) Gi human rat human human
rat		 human √
Dopamine D2 DRD2(L) Gi human rat human human √
Dopamine D3 DRD3 Gi human
human		 human √
Dopamine D4 DRD4 Gi human human √
Dopamine D5 DRD5 Gs human mouse
rat		 human human human √
Class A Orphan GPR183 EBI2 Gi human √
Lysophospholipid S1P1 EDG1 Gi human mouse human mouse human human human √
Lysophospholipid LPA1 EDG2 Gi human human human √
Lysophospholipid S1P3 EDG3 Gi human
human		 human human human √
Lysophospholipid LPA2 EDG4 Gi human human human √
Lysophospholipid S1P2 EDG5 Gs human mouse
canine
rat
simian		 human human √
Lysophospholipid S1P4 EDG6 Gi human mouse √
Lysophospholipid LPA3 EDG7 Gi & Gq human human √
Lysophospholipid S1P5 EDG8 Gi human √
Endothelin ETA EDNRA Gq human mouse human mouse √
Endothelin ETB EDNRB Gi, Gs, & Gq human mouse human mouse human human √
Protease activated PAR1 F2R Gi human human √
Protease activated PAR2 F2RL1 Gi & Gq human
human		 human
human		 human human √
Protease activated PAR4 F2RL3 Gi & Gq human human human √
Free Fatty Acid FFA1 FFAR1(GPR40) Gs & Gq human human √
Free Fatty Acid FFA3 FFAR2(GPR43) Gq human √
Free Fatty Acid FFA3 FFAR3(GPR41) Gi human √
Formylpeptide FPR FPR1 Gq human mouse human human human √
Formylpeptide ALX FPRL1 Gi human
human		 human
human		 human human human human √
Glycoprotein Hormone Receptor FSH FSHR Gs human
human		 human human √
GABAB Receptor GABAB GABBR1+GABBR2 Gi human √
Galanin GAL1 GALR1 Gi human mouse human human human human human √
Galanin GAL2 GALR2 Gi human mouse human mouse human human human √
Glucagon Glucagon GCGR Gs human mouse human human human human √
Glucagon GHRH GHRHR Gs human human √
Ghrelin GRLN GHSR1a Gq human mouse human √
Glucagon GIP GIPR Gs human mouse human human
mouse		 human
mouse		 human √
Glucagon GLP-1 GLP1R Gs human mouse human mouse human human human human √
Glucagon GLP-2 GLP2R Gs human human human human human √
Gonadotrophin-releasing Hormone Receptor GnRH GNRHR Gi & Gq human √
Bile Acid Receptors GPR131 GPBAR1 Gs human human human √
Class A Orphan GPR1 GPR1 N/A human mouse human human √
Class A Orphan GPR35 GPR35 N/A human human human human √
Class A Orphan GPR39 GPR39 Gq human √
Class A Orphan GPR55 GPR55 N/A human human √
Class A Orphan GPR81 GPR81 Gi human human √
Class A Orphan GPR84 GPR84 Gi human human human √
Lysophospholipid LPAR5 GPR92 Gq human human √
Nicotinic Acid HM74A GPR109A Gi human human human √
Nicotinic Acid N/A GPR109B Gi human human human √
Class A Orphan GPR119 GPR119 N/A human
human		 √
Class A Orphan GPR120(S) GPR120(S) N/A human √
Class A Orphan GPR120 GPR120 N/A mouse √
Class A Orphan GPR120(L) GPR120(L) N/A human human human √
Glutamate mGlu1 GRM1 Gq human √
Glutamate mGlu2 GRM2 Gi human √
Glutamate mGlu3 GRM3 Gi human √
Glutamate mGlu4 GRM4 Gi human human √
Glutamate mGlu5 GRM5 Gq human √
Glutamate mGlu6 GRM6 Gi human human √
Bombesin BB2 GRPR Gq human
human		 human human human √
Orexin OX1 HCRTR1 Gq human mouse human human √
Orexin OX2 HCRTR2 Gq human human human √
Histamine H1 HRH1 Gq human human √
Histamine H2 HRH2 Gs human human human human √
Histamine H3 HRH3 Gi human human human human √
Histamine H4 HRH4 Gi human √
Serotonin 5HT1A HTR1A Gi human human human √
Serotonin 5HT1B HTR1B Gi human human human √
Serotonin 5HT1E HTR1E Gi human √
Serotonin 5HT1F HTR1F Gi human human human √
Serotonin 5HT2A HTR2A Gq human mouse human human √
Serotonin 5HT2B HTR2B Gq human √
Serotonin 5HT2C HTR2C Gq human mouse human human human √
Serotonin 5HT5A HTR5A Gi & Gq human human √
Serotonin 5HT6 HTR6 Gq human √
Serotonin 5HT7A HTR7A Gs human √
Serotonin 5HT7B HTR7B Gs human √
Serotonin 5HT7D HTR7D Gs human √
KISS1-derived Peptide Receptor GPR54 KISS1R Gq humanhuman mouse human √
Luteneizing Hormone LH LHCGR Gs human human human √
Leukotriene BLT1 LTB4R Gi & Gq human mouse human human human human √
Melanocortin MC1 MC1R Gs human human human
human		 √
Melanocortin MC3 MC3R Gs human mouse human human human human √
Melanocortin MC4 MC4R Gs human mouse human human human √
Melanocortin MC5 MC5R Gs human
human		 mouse human human √
Melanin-Concentrating Hormone Receptor MCH1 MCHR1 Gi human mouse human human √
Melanin-Concentrating Hormone Receptor MCH2 MCHR2 Gq human human √
Motilin motilin MLNR Gq human human human √
Class A Orphan MRGX2 MRGPRX2 Gq human human √
Melatonin MT1 MTNR1A Gi & Gq human human human human √
Melatonin MT2 MTNR1B Gi human human human human √
Neuromedin U NMU1 NMU1R Gq human human human √
Neuropeptide B & W GPR7 NPBWR1 Gi human human human √
Neuropeptide B & W GPR8 NPBWR2 Gi human human human
human		 √
Neuropeptide F GPR147 NPFFR1 Gi human human human √
Neuropeptide F GPR74 NPFFR2 Gi human human √
Neuropeptide S NPS NPSR1 Gq & Gs human √
Neuropeptide Y Y1 NPY1R Gi human mouse human human √
Neuropeptide Y Y2 NPY2R Gi human mouse human human human human √
Neurotensin NTS1 NTSR1 Gq human human human √
Opioid δ OPRD1 Gi human
human		 mouse human mouse human human human human √
Opioid κ OPRK1 Gi human mouse mouse human human human √
Opioid NOP OPRL1 Gi human human human human √
Opioid µ OPRM1 Gi human
human
human		 mouse
rat		 human
human		 mouse
rat		 human human human √
Class A Orphan GPR99 OXGR1 Gq human √
Eicosanoid receptor GPR170 OXER1 Gi human human √
Vasopressin OT OXTR Gi & Gq human mouse human human human √
P2Y P2Y1 P2RY1 Gq human human √
P2Y P2Y2 P2RY2 Gq human human human √
P2Y P2Y4 P2RY4 Gq human
human		 human human human √
P2Y P2Y6 P2RY6 Gq human mouse human √
P2Y P2Y11 P2RY11 Gs & Gq human human human √
P2Y P2Y12 P2RY12 Gi human mouse human mouse √
Neuropeptide Y Y4 PPYR1(NPY4R) Gi human mouse human human human √
Prolactin Releasing Peptide Receptor PRRP PRLHR Gq human human human √
Prokineticin PKR1/GPR73 PROKR1 Gq & Gs human rat human rat human human √
Prokineticin PKR2 PROKR2 Gs human rat human rat human √
Platelet-activating factor PAF PTAFR Gi & Gq human mouse human mouse human human √
Prostanoid DP1 PTGDR Gs human human √
Prostanoid EP1 PTGER1 Gq & Gi human √
Prostanoid EP2 PTGER2 Gs human
human		 human √
Prostanoid EP3 PTGER3 Gi human human human human √
Prostanoid EP4 PTGER4 Gq human
human		 human human √
Prostanoid FP PTGFR Gq human human human √
Prostanoid IP1 PTGIR Gs human
human		 mouse human human human √
PTH receptor PTH1 PTHR1 Gs human human human human human human √
PTH receptor PTH2 PTHR2 Gs human human human human human √
Relaxin LGR7 RXFP1 Gs human human √
Relaxin LGR8 RXFP2 Gs human √
Relaxin SALPR RXFP3 Gi human human human human √
Relaxin RXFP4 RXFP4 Gi human human √
Secretin SEC SCTR Gs human
human		 human human human human √
Somatostatin SST1 SSTR1 Gi human human √
Somatostatin SST2 SSTR2 Gi human mouse human human human human human √
Somatostatin SST3 SSTR3 Gi human
human		 human human
human		 √
Somatostatin SST4 SSTR4 Gi human human human human √
Somatostatin SST5 SSTR5 Gi human
human		 mouse human human √
Succinate Receptor SUCNR1 GPR91 N/A human mouse √
Tachykinin NK1 TACR1 Gs human
human		 mouse human human √
Tachykinin NK2 TACR2 Gs & Gq human human human human √
Tachykinin NK3 TACR3 Gs human
human		 human human human human √
Prostanoid TP TBXA2R Gq human human √
TRH TRH TRHR Gq human human √
Glycoprotein Hormone Receptor TSH TSHR(L) Gs & Gq human human √
Urotensin UT UTR2 Gq human mouse human mouse human √
VIP & PACAP VPAC1 VIPR1 Gs human mouse human mouse human human human √
VIP & PACAP VPAC2 VIPR2 Gs human human human human human √
Chemokine XC1 XCR1 Gi human human √

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Orphan GPCR
Orphan GPCR Gene GenBank Accession Number Cell Line Ligand-Based Clone PathHunter® β-Arrestin
Orphan GPCR		 PathHunter® eXpress
β-Arrestin Orphan GPCR		 Available as Service
BAI1 NM_001702.2 CHO 93-0545C2 93-0545E2CP1 √
BAI2 NM_001703.2 CHO 93-0546C2 93-0546E2ACP1 √
BAI3 NM_001704.2 CHO 93-0547C2 93-0547E2ACP1 √
CCRL2 NM_003965.2 CHO 93-0333C2A 93-0333E2ACP1 √
CMKLR1 NM_004072 CHO Chemerin 93-0313C2 93-0313E2C1 √
DARC NM_002027 CHO 93-0548C2 93-0548E2ACP1 √
EBI2 NM_080818.2 CHO 7α, 25-dihydroxycholesterol 93-0437C2A 93-0437E2ACP1 √
GHSR1b NM_004122 CHO 93-0354C2A 93-0354E2ACP1 √
GPR1 NM_005279.1 CHO Chemerin 93-0335C2 93-0335E2C2 √
GPR3 NM_005281.2 CHO 93-0626C2 93-0626E2CP1 √
GPR4 NM_005282.1 CHO 93-0369C2A √
GPR6 NM_005284.2 CHO 93-0634C2 93-0634E2CP1 √
GPR6 NM_005284.2 U2OS 93-0634C3 93-0634E3CP1 √
GPR12 NM_005288.1 CHO 93-0329C2A 93-0329E2ACP1 √
GPR15 NM_005290.1 CHO 93-0682C2 93-0682E2CP1 √
GPR17 NM_005291.1 CHO 93-0633C2 93-0358E2ACP1 √
GPR18 NM_005292 CHO 93-0560C2A 93-0560E2ACP1 √
GPR20 NM_005293.1 HEK 93-0405C1 93-0405E1CP1 √
GPR23 NM_005296.1 CHO 93-0336C2A 93-0336E2ACP1 √
GPR25 NM_005298.1 CHO 93-0368C2A 93-0368E2ACP2 √
GPR26 NM_153442.1 CHO 93-0392C2A 93-0392E2ACP1 √
GPR27 NM_018971.1 CHO 93-0334C2A 93-0334E2ACP1 √
GPR30 NM_001505 CHO 93-0373C2A 93-0373E2ACP2 √
GPR31 NM_005299.1 HEK 93-0406C1 93-0406E1CP1 √
GPR32 NM_001506.1 CHO 93-0321C2A 93-0321E2ACP2 √
GPR35 NM_005301.2 CHO Zaprinast 93-0355C2 93-0355E2C2 √
GPR37 NM_005302.2 CHO 93-0339C2A 93-0339E2ACP1 √
GPR37L1 NM_004767.2 CHO 93-0378C2A 93-0378E2ACP1 √
GPR39 NM_001508.1 CHO 93-0338C2 93-0338E2CP1 √
GPR45 NM_007227.3 HEK 93-0374C1A √
GPR45 NM_007227.3 CHO 93-0374C2A 93-0374E2ACP1 √
GPR50 NM_004224 CHO 93-0648C2 √
GPR52 NM_005684.1 CHO 93-0371C2A 93-0371E2ACP1 √
GPR52 NM_005684.1 U2OS 93-0371C3 √
GPR55 NM_005683.3 CHO AM251; LPI soy 93-0245C2 93-0245E2C1 √
GPR61 NM_031936.2 CHO 93-0407C2A 93-0407E2ACP1 √
GPR65 NM_003608.2 CHO 93-0428C2A 93-0428E2ACP1 √
GPR75 NM_006794.1 CHO 93-0363C2A 93-0363E2ACP1 √
GPR78 NM_080819.1 CHO 93-0370C2A 93-0373E2ACP1 √
GPR79 NM_001272 CHO 93-0408C2A 93-0408E2ACP1 √
GPR81 NM_032554 CHO L-Lactate 93-0330C2A 93-0330E2ACP1 √
GPR83 NM_016540.2 CHO 93-0441C2A 93-0441E2ACP1 √
GPR84 NM_020370.1 CHO Embellin 93-0647C2 93-0360E2ACP1 √
GPR85 NM_018970.3 CHO 93-0409C2A 93-0409E2ACP1 √
GPR85 NM_018970.3 U2OS 93-0409C3 93-0409E3CP1 √
GPR88 NM_022049.1 CHO 93-0357C2A 93-0357E2ACP1 √
GPR91 NM_033050.1 CHO Succinate 93-0331C2A 93-0331E2ACP1 √
GPR97 NM_170776 CHO 93-0410C2A 93-0410E2ACP1 √
GPR101 NM_054021 CHO 93-0831C2 √
GPR103 NM_198179 CHO 93-0376C2A √
GPR107 NM_020960 CHO 93-0419C2A 93-0419E2ACP1 √
GPR109A NM_177551 CHO Nicotinic Acid 93-0301C2 93-0301E2C2 √
GPR119 NM_178471 HEK Oleoylethanolamide 93-0356C1 √
GPR119 NM_178471 U2OS Oleoylethanolamide 93-0356C3 √
GPR120(L) NM_181745.1 CHO GW9508 93-0366C2 93-0366E2C1 √
GPR123 NM_001083909 CHO 93-0417C2A 93-0417E2ACP1 √
GPR132 NM_013345.2 CHO 93-0411C2A 93-0411E2ACP1 √
GPR135 NM_022571.3 CHO 93-0431C2A 93-0431E2ACP1 √
GPR137 NM_003272 CHO 93-0361C2A 93-0361E2ACP2 √
GPR139 NM_171791 HEK 93-0412C1A √
GPR139 NM_171791 CHO 93-0412C2A 93-0412E2ACP2 √
GPR141 NM_181791.1 CHO 93-0385C2A 93-0385E2ACP1 √
GPR142 NM_181790.1 CHO 93-0413C2A 93-0413E2ACP1 √
GPR143 NM_000273 CHO 93-0362C2A 93-0362E2ACP1 √
GPR146 NM_138445.1 CHO 93-0365C2A 93-0365E2ACP1 √
GPR148 XM_293092.1 CHO 93-0364C2A 93-0364E2ACP1 √
GPR149 XM_293580.1 CHO 93-0420C2A 93-0420E2ACP1 √
GPR150 XM_209675 HEK 93-0375C1A 93-0375E2ACP1 √
GPR150 XM_209675 CHO 93-0375C2A √
GPR151 NM_194251 CHO 93-0381C2A √
GPR152 XM_352045 HEK 93-0384C1A √
GPR152 XM_352045 CHO 93-0384C2A √
GPR157 NM_024980 CHO 93-0414C2A 93-0414E2ACP2 √
GPR161 NM_153832.1 CHO 93-0705C2 √
GPR162 NM_019858 CHO 93-0383C2A 93-0383E2ACP1 √
GPR171 NM_013308.2 CHO 93-0415C2A 93-0415E2ACP1 √
GPR173 NM_018969.3 HEK 93-0380C1A √
GPR173 NM_018969.3 CHO 93-0380C2A 93-0380E2ACP1 √
GPR176 NM_007223 CHO 93-0382C2A 93-0382E2ACP1 √
GPR182 NM_007264 CHO 93-0754C2 √
LGR4 NM_018490.1 CHO 93-0516C2A 93-0516E2ACP1 √
LGR5 NM_003667 CHO 93-0526C2A 93-0526E2ACP1 √
LGR6 XM_097508 CHO 93-0527C2A 93-0527E2ACP1 √
MRGPRD NM_198923 CHO 93-0542C2A 93-0542E2ACP2 √
MRGPRE XM_171536.3 CHO 93-0438C2A 93-0438E2ACP1 √
MRGPRF NM_145015 CHO 93-0433C2A 93-0433E2ACP2 √
MRGPRX1 NM_147199 CHO 93-0540C2A 93-0540E2ACP1 √
MRGPRX4 NM_054032 CHO 93-0541C2A 93-0541E2ACP1 √
OPN5 NM_181744.2 CHO 93-0704C2 93-0704E2CP1 √
OXGR1 NM_080818 CHO 93-0693C2 93-0693E2CP1 √
P2RY8 NM_178129 CHO 93-0635C2 93-0635E2CP1 √
TAAR5 NM_003967 CHO 93-0718C2 93-0718E2CP1 √

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Kinases
Kinase Gene Partner Protein Cell Line PathHunter®
Receptor Tyrosine		 PathHunter® Receptor
Tyrosine eXpress		 Other PathHunter® Assays PathHunter®
Cytosolic Tyrosine		 PathHunter® Cytosolic
Tyrosine eXpress		 Available
as Service
AXL P85 U2OS √
c-KIT P85 U2OS 93-0853C3 √
c-MET GrB2 U2OS 93-0632C3 √
c-Ret-GFRα2 SHC1 U2OS 93-0816C3 93-0816E3CP16 √
CSF3R-JAK1 SHC1 U2OS 93-0809C3 93-0809E3CPO √
DDR1 SHC1 U2OS 93-0578U3 93-0578E3CP16 √
DDR2 PLCG1 U2OS 93-0711U3 √
EphA4 PLCG1 U2OS 93-0877C3 √
EphA5 PLCG1 U2OS 93-0840C3 93-0840E3CP16 √
EphA7 PLCG1 U2OS 93-0841C3 √
EphA10 PLCG1 U2OS √
EphB3 SHC1 U2OS 93-0842C3 93-0842E3CP16 √
EphB2 SHC1 U2OS 93-0848C3 93-0848E3CP16 √
EphB4 SHC1 U2OS 93-0468C3 93-0468E3CP16 √
EphB6 PLCG1 U2OS √
ErbB1 PLCG1 U2OS 93-0681C3 √
ErbB2-ErbB3 GrB2 U2OS 93-0535C3 93-0535E3CP16 √
ErbB4 SHC1 U2OS 93-0465C3 √
FGFR1 PLCG2 U2OS 93-0850E3CP16 √
Flt3 P85 U2OS 93-0506C3 93-0506E3CP16 √
Flt4 GrB2 U2OS √
GHR-JAK1 PLCG1 U2OS 93-0756C3 93-0756E3CPO √
GHR-JAK2 PLCG1 U2OS 93-0829C3 93-0829E3CPO √
PRLR-JAK1 PLCG1 U2OS 93-0686C3 93-0686E3CPO √
PRLR-JAK2 PLCG1 U2OS 93-0687C3 93-0687E3CPO √
IGF1R SHC1 HEK 93-0505C1 93-0505E1CP17 √
INSR PLCG1 U2OS 93-0466C3 93-0466E3CP16 93-0808C3 √
JAK3 PLCG1 U2OS √
PDGFRa PLCG1 U2OS 93-0823C3 93-0823E3CP16 √
PDGFRb PLCG1 U2OS 93-0493C3 93-0493E3CP16 √
SYK PLCG1 U2OS √
TrkA SHC1 U2OS 93-0462C3 93-0462E3CP16 √
TrkA-P75 SHC1 U2OS 93-0529C3 93-0529E3CP16 √
TrkB SHC1 U2OS 93-0463C3 √
TrkB-P75 SHC1 U2OS 93-0530C3 93-0530E3CP16 √
TrkC SHC1 U2OS 93-0464C3 93-0464E3CP16 √
TrkC-P75 SHC1 U2OS 93-0531C3 93-0531E3CP16 √
TYK2 PLCG1 U2OS √

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NHRs
NHR Gene NHR Description Cell Line Nuclear Translocation Assays Protein Interaction Assays Available as Service
AR Androgen Receptor CHO 93-0454C2 √
AR Androgen Receptor HEK 93-0177C1 √
ERα Estrogen Receptor alpha CHO 93-0453C2 √
ERRα Estrogen Related Receptor alpha CHO 93-0328C2 √
FXR Farnesoid X-activated Receptor CHO 93-0443C2 √
GR Glucocorticoid Receptor CHO 93-0002 93-0456C2 √
LXRα Liver X Receptor alpha CHO 93-0215C2 93-0389C2 √
LXRβ Liver X Receptor beta CHO 93-0442C2 √
LXRβ-NCoR1 Liver X Receptor beta HEK 93-0856C1 √
MR Mineralocorticoid Receptor CHO 93-0451C2 93-0758C2 √
PPARα Peroxisome Proliferator Activated Receptor alpha CHO 93-0457C2 √
PPARδ Peroxisome Proliferator Activated Receptor delta CHO 93-0492C2 √
PPARγ Peroxisome Proliferator Activated Receptor gamma CHO 93-0390C2 √
PRα Progesterone Receptor alpha U2OS 93-0852C3 √
PRβ Progesterone Receptor beta U2OS 93-0484C3 93-0851C3 √
RARα Retinoic Acid Receptor alpha CHO 93-0325C2 √
RARβ Retinoic Acid Receptor beta CHO 93-0326C2 √
RORγ Retinoid Related Orphan Receptor U2OS 93-0461C3 √
RXRα Retinoid X Receptor alpha U2OS 93-0439C3 √
RXRγ Retinoid X Receptor gamma CHO 93-0327C2 √
THRα Thyroid Hormone Receptor alpha CHO 93-0324C2 √
THRβ Thyroid Hormone Receptor beta CHO 93-0391C2 √

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Pathway Assays
Pathway Gene Cell Line Assay Measures PathHunter®
Pathway Assays		 PathHunter®
Pathway eXpress		 PathHunter® Mitotic
Index Assays		 Available
as Service
Cdc25a U2OS Cdc25a Degradation 93-0765C3 93-0765E3CP5CDC √
Cdc25a NCI H-460 Cdc25a Degradation 93-0776C12 √
Keap1-NRF2 U2OS NRF2 Translocation 93-0821C3 √
Mitotic Index CHO Nuclear Envelope Degradat 93-0006 √
Mitotic Index HEK Nuclear Envelope Degradat 93-0052 √
Mitotic Index U2OS Nuclear Envelope Degradat 93-0284 √
NFκB HEK IκB Degradation 93-0538E1CP7PTI √
NPR1 CHO NPR1 Activation 93-0804C2 √
p53 U2OS p53 Nuclear Translocation 93-0757C3 √
PDK/AKT U2OS FOXO Translocation 93-0539E3CPPDK √
PI3 U2OS FOXO Translocation 93-0539E3CP0PI3 √
SREBP2 U2OS SREBP2 Translocation 93-0830C3 √
TORC1(CRTC1) U2OS TORC1 Translocation 93-0833C3 √
TORC2(CRTC2) U2OS TORC2 Translocation 93-0813C3 √
TNFα HEK IκB Degradation 93-0538E1CP7TNF √
Wnt3 U2OS β-Catenin Translocat 93-0743E3CP22WNT √
Wnt3-GSK3β U2OS β-Catenin Translocat 93-0743E3CP22GSK3 √
Wnt-Fz GSK3β U2OS β-Catenin Translocat √
XBP1 U2OS XBP1 Translocation 93-0857C3 √

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Proteases
Protease Assays Protease Description PathHunter® Cell-Based
Protease Assays		 HitHunter®
Protease Assays		 Available as Service
ADAM10 A PathHunter® cell line for ADAM10 screening 93-0445C1 √
β-Secretase HitHunter® β-Secretase Assay (Chemiluminescent) 90-0029 √
Caspase HitHunter® Caspase-3 Assay (Fluorescent) 90-0027 √
Caspase 3 HitHunter® Caspase-3 Assay (Chemiluminescent) 90-0028 √
Eastern Blot Measures expressed ProLabel™ tagged protein 93-0053 √
PCSK9 A PathHunter® cell line for studying dosage, potency, effect of small molecule inhibitors of PCSK9 secretion 93-0440C1 √
Renin HitHunter® Renin Assay 90-0094 √
Secretion Detection Detecting and measuring ProLabel (PL) or ProLink (PK) tagged proteins in whole cells following secretion into cell culture media 93-0273 √

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